AVALIAÇÃO DO POTENCIAL TÓXICO DA SOLUÇÃO NASAL DE CLORIDRATO DE NAFAZOLINA COMERCIAL ATRAVÉS DO BIOENSAIO COM ALLIUM CEPA L

Abstract

This study investigated the toxicity of naphazoline hydrochloride nasal solution using the Allium cepa plant model. The aim was to assess the effects of this substance on the environment and the potential toxicity due to inappropriate use and incorrect disposal of the drug. Toxicity tests were carried out on Allium cepa seeds and bulbs, observing germination rates and root growth at different concentrations of the nasal solution. The results showed a progressive improvement in germination rates and root size as concentrations of naphazoline increased, with the most concentrated treatments resulting in a total detrimental effect on germination and root growth. An analysis indicated that naphazoline hydrochloride has a dose-dependent inhibitory effect on plant development, pointing to the need for caution in the use and disposal of the drug. The research highlights the importance of further studies to investigate the specific effects of the components of the nasal solution, such as naphazoline hydrochloride and benzalkonium chloride, in more advanced biological models.