ASSOCIAÇÃO ENTRE A DIABETES MELLITUS TIPO 2 E A DOENÇA DE ALZHEIMER: RELAÇÕES METABÓLICAS E IMPLICAÇÕES NEUROLÓGICAS

Abstract

The association between type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) has been linked to insulin resistance. Any disorder in insulin secretion by the pancreas that leads to hyperinsulinemia may be related to cognitive decline. A diminished response to insulin in the brain is characteristic and directly contributes to the degeneration impact. AD may be referred to as type 3 diabetes (T3DM), suggesting the possibility that the disease is a variant of diabetes that specifically affects the brain. The aim of this review is to analyze the association between T2DMand AD, focusing on clinical aspects, molecular mechanisms involved in the association of the diseases, diagnosis, and treatment. The bibliographic research was based on the association of health descriptors, type 2 diabetes, Alzheimer's disease, clinical aspects, molecular mechanisms, diagnosis, and treatment. It is considered that T2DM may lead to the development of AD and contribute to the progression of the disease through hyperinsulinemia, causing significant damage to the central nervous system (CNS), leading to neurodegeneration.