RELAÇÃO ENTRE PRIVAÇÃO DE SONO, MICROBIOTA INTESTINAL E REGULAÇÃO DO APETITE: Implicações para o desenvolvimento da obesidade

Abstract

Objective: Sleep deprivation has been associated with, and more recently implicated in changes in the gut microbiota. These aspects are important risk factors for the development of obesity. In this context, this study aimed to analyze how reduced sleep duration can alter the composition of the gut microbiota, appetite regulation, and eating behavior. The issue investigated is based on evidence that poor sleep patterns induceMethodology and Results: A literature review was conducted through a structured search in Google Scholar, PubMed, and SciELO, selecting articles published between 2015 and 2025 that addressed sleep deprivation, gut microbiota, and obesity. Overall, the findings indicate that insufficient sleep reduces microbial diversity, alters the proportion of genera such as Firmicutes and Bacteroidetes, and increases intestinal permeability. Additionally, sleep deprivation leads to elevated ghrelin levels, reduced leptin levels, and greater consumption of hypercaloric foods, contributing to increased adiposity. Conclusion: It is concluded that an impaired sleep pattern (in quantity and quality) directly influences hormonal mechanisms and the microbiota profile related to energy metabolism, reinforcing the importance of strategies that promote adequate sleep in the prevention of obesity.