O USO CRÔNICO DE ANTI-INFLAMATÓRIOS NÃO ESTEROIDAIS EM IDOSOS ASSOCIADO À INCIDÊNCIA DE NEFROPATIAS

Abstract

The present work aims to identify whether the manifestations of nephropathies in the elderly may be associated with the indiscriminate use of non-steroidal anti inflammatory drugs (NSAIDs), associating the adverse effects of this class of medications that occur through the inhibition of cyclooxygenases, preventing arachidonic acid from being converted into prostaglandin, which has an important role in renal physiology, acting as vasodilators and increasing renal perfusion, considering increased age and consequently decreased renal perfusion as a risk factor. The objective of the work is to carry out a study on the interactions of non-steroidal anti inflammatory drugs in cases of nephropathy in the elderly. To this end, bibliographical research of qualitative nature was carried out, analyzing scientific articles and monographs published in SciELO, Google Scholar, Scientific Journals in the area of pharmacy and medicine, in the period from 2009 to 2023. The study showed that the adverse effects of NSAIDs, associated with decreased renal function, due to physiological processes of aging, can lead to irreversible cases of nephropathies. It is concluded that the use of any class of NSAIDs can generate or worsen nephropathies in elderly patients, which is why their use must be accompanied by a health professional, thus highlighting the importance of the pharmaceutical professional in the rational use of medicines.