AVANÇOS TERAPÊUTICOS: aplicação de anticorpos monoclonais no tratamento do câncer de mama

Abstract

Breast cancer represents a serious public health issue in Brazil and worldwide, as it is the most frequent neoplasia in women, underscoring the importance of early diagnosis, which plays a crucial role in increasing cure potential through targeted treatments. This study aimed to address the use of monoclonal antibodies (mAbs) in the treatment of breast cancer. The objective is to analyze the main characteristics and clinical efficacy of mAbs, highlighting target antigens, mechanisms of action, andadverse reactions, comparing data on the impact on patient survival and quality of life. The methodology used was a literature review in electronic databases, including the Scientific Electronic Library Online (SciELO), the Virtual Health Library (BVS), and the CAPES Journal Portal. The results indicate that mAbs, especially when combined with chemotherapy, significantly reduce the risk of recurrence and mortality. Although adverse effects, such as cardiotoxicity, present a relevant limitation, the conclusions suggest that the clinical benefits of these treatments justify ongoing development and adoption of this class of medication, expanding oncological research prospects in breast cancer.