Abstract:
Introduction: Vitamin D has been the subject of several studies demonstrating its
action on physiological mechanisms, one of which is its effectiveness in the treatment
and prevention of depression. Its therapeutic use in the treatment of this pathology
has raised evidence that proves its modulating and regulatory properties influencing
depression. Therefore, a review study highlighting its applications and influence is
justified. Objective: This study aimed to conduct a review of the literature published
between 2019 and 2024, highlighting the action and benefits of the use of vitamin D
in depressive disorders. Methodology: A bibliographic review was carried out in the
Brazilian Digital Library of Theses and Dissertations (BDTD). 32 studies were
verified, including theses and dissertations, of which 23 were discarded because they
did not comply with previously established criteria, such as studies on animals,
language of publication, and others, which were not in line with the proposed theme.
Results and discussion: The results presented demonstrate that vitamin D has a
positive effect on depression, showing that inadequate or insufficient levels (< = 20 -
29 ng/ml) are conducive to worsening of the condition and symptoms. When the level
is sufficient or adequate (= 30 or > 30 ng/ml), the symptoms or disorder significantly
improve. Other correlated factors were exposure to sunlight and lifestyle. Final
considerations: The review demonstrates that vitamin D has positive effects on
depression at adequate levels and its application suggests further studies, aiming at
contributing to the prevention and treatment of depressive disorder.
