CARRIJO, Hemilly Gabriele Vidal; PINTO, Luciano Filho Roriz; SIQUEIRA, Luiz Felipe Rodrigues
Abstract:
Third molar surgery is one of the most common procedures in dentistry but is often
associated with postoperative complications such as pain, edema, trismus, alveolitis,
and infections. This study aimed to critically review the scientific literature on the mainstrategies for preventing and managing these complications, identifying the most
effective and safe approaches. It is a qualitative literature review based on research in
PubMed, BVS, and Google Scholar databases, covering the period from 2015 to 2025.
Clinical trials, observational studies, and reviews addressing complications arising
from third molar extractions and the pharmacological, surgical, and adjunctive
measures used for their control were included. The results indicated that the use of
nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids is effective in
controlling pain and swelling, while prophylactic antibiotic therapy should be indicated
only in specific cases due to the risk of bacterial resistance. Less invasive techniques,
chlorhexidine irrigation, and cryotherapy proved effective in reducing morbidity.
Innovative approaches such as platelet-rich fibrin (PRF), photobiomodulation, and
natural products like honey showed therapeutic potential in accelerating healing and
controlling inflammation. It is concluded that the integration of pharmacological,
surgical, and biotechnological therapies, combined with individualized treatment, is
essential to optimize outcomes and reduce postoperative complications in third molar
surgeries.