Abstract:
The use of cannabidiol has been widely investigated as a therapeutic alternative in the
treatment of epilepsy, especially in pharmacoresistant cases. The objective of this
study was to analyze, through an integrative literature review, the scientific evidence
regarding the efficacy, mechanisms of action, and safety of cannabidiol in the control of
epileptic seizures. The methodology consisted of searching scientific articles in national
and international databases, using descriptors related to cannabidiol and epilepsy.
Studies published in Portuguese, English, and Spanish, available in full text and
addressing the use of cannabidiol in the treatment of epilepsy, were included, whileduplicate publications or those that did not meet the established criteria were excluded.
The results demonstrated that cannabidiol promotes a significant reduction in the
frequency and intensity of epileptic seizures, particularly in severe epilepsy syndromes
resistant to conventional treatment. Its action was found to be associated with
modulation of the endocannabinoid system and the balance between excitatory and
inhibitory neurotransmitters. Regarding safety, the reported adverse effects were
mostly mild to moderate. It is concluded that cannabidiol presents relevant therapeutic
potential in the treatment of epilepsy; however, further studies are needed to
standardize dosages, assess long-term effects, and expand its safe clinical use.
