DOMINGUES, Pedro Henrique Assis; ALMEIDA, Rafaela de Oliveira; BARCELOS, Jeferson Borges
Abstract:
Bovine mastitis is one of the diseases with the greatest impact on dairy farming, both
due to the economic losses resulting from decreased milk production and discard,
and due to the increasing resistance to antimicrobials. Given this scenario, the
present study aimed to evaluate the antimicrobial activity of Khaya grandifoliola
extract against Staphylococcus aureus, a microorganism frequently associated with
the etiology of mastitis. The investigation is based on the search for natural
alternatives capable of complementing or reducing the dependence on conventional
antibiotics in the treatment of the disease. To this end, alcoholic extraction of the
plant bark was performed, followed by fractionation in solvents of different polarities.
The extracts obtained were subjected to in vitro assays in 48-well plates to determine
their antimicrobial potential. The methodology adopted considered principles related
to bacterial resistance, veterinary phytotherapy, and the study of bioactive
compounds present in medicinal species. The results showed that the extract had aninhibitory effect on the pathogenic strain of Staphylococcus aureus, indicating that
African mahogany is emerging as a promising phytotherapeutic alternative in the
control of bovine mastitis.
