AVALIAÇÃO DE UM EXTRATO À BASE DE MOGNO AFRICANO (KHAYA GRANDIFOLIOLA) NO CONTROLE DA STAPHYLOCOCCUS AUREUS

Abstract

Bovine mastitis is one of the diseases with the greatest impact on dairy farming, both due to the economic losses resulting from decreased milk production and discard, and due to the increasing resistance to antimicrobials. Given this scenario, the present study aimed to evaluate the antimicrobial activity of Khaya grandifoliola extract against Staphylococcus aureus, a microorganism frequently associated with the etiology of mastitis. The investigation is based on the search for natural alternatives capable of complementing or reducing the dependence on conventional antibiotics in the treatment of the disease. To this end, alcoholic extraction of the plant bark was performed, followed by fractionation in solvents of different polarities. The extracts obtained were subjected to in vitro assays in 48-well plates to determine their antimicrobial potential. The methodology adopted considered principles related to bacterial resistance, veterinary phytotherapy, and the study of bioactive compounds present in medicinal species. The results showed that the extract had aninhibitory effect on the pathogenic strain of Staphylococcus aureus, indicating that African mahogany is emerging as a promising phytotherapeutic alternative in the control of bovine mastitis.